ELK Biotechnology CNST rabbit pAb
CNST 단백질을 인식하는 토끼 폴리클로날 항체로, WB에 적합합니다. 인간 및 생쥐 시료에 반응하며, 세포막 및 골지체 관련 단백질 연구에 활용됩니다. 합성 펩타이드 면역원으로 제작되어 높은 특이성을 제공합니다.
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ELK Biotechnology CNST rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | CNST rabbit pAb |
| Applications | WB |
| Recommended Dilutions | WB 1:500–2000 |
| Immunogen | Synthesized peptide derived from human CNST (AA range: 296–346) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 163882 |
| Human Swiss-Prot No. | Q6PJW8 |
| Species Reactivity | Human, Mouse |
세포 내 위치 (Cellular Localization)
Cell membrane; single-pass membrane protein.
Golgi apparatus, trans-Golgi network membrane; single-pass membrane protein.
Cytoplasmic vesicle, secretory vesicle.
Located predominantly in the trans-Golgi network.
Probably trafficks between the trans-Golgi network and the cell membrane via the secretory pathway.
배경 (Background)
Targeting of numerous transmembrane proteins to the cell surface is thought to depend on their recognition by cargo receptors that interact with the adaptor machinery for anterograde traffic at the distal end of the Golgi complex.
Consortin (CNST) is an integral membrane protein that acts as a binding partner of connexins, the building blocks of gap junctions, and acts as a trans-Golgi network (TGN) receptor involved in connexin targeting to the plasma membrane and recycling from the cell surface (del Castillo et al., 2010 [PubMed 19864490]).
[supplied by OMIM, Jun 2010]
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