ELK Biotechnology CYH2 rabbit pAb
CYH2 rabbit pAb는 인간 CYH2 단백질을 인식하는 폴리클로날 항체로, WB 실험에 적합합니다. 합성 펩타이드 면역원으로 제작되었으며, 사람·생쥐·랫드에 반응합니다. -20°C에서 1년간 안정적으로 보관 가능하며, 세포막 및 세포 접합부 등 다양한 세포 위치에 발현된 CYH2 단백질 검출에 활용됩니다.
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제품명
CYH2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB |
| Recommended Dilutions | WB 1:500–2000 |
| Immunogen | Synthesized peptide derived from human CYH2 (AA range: 156–206) |
| Species Reactivity | Human, Mouse, Rat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 9266 |
| Human Swiss-Prot No | Q99418 |
| Storage | -20°C / 1 year |
| Host | Rabbit |
세포 내 위치 (Cellular Localization)
Cell membrane; Peripheral membrane protein; Cytoplasm; Cell projection; Growth cone; Tight junction; Adherens junction.
Both isoform 1 and 2 are recruited to the cell membrane through association with ARL4A, ARL4C, and ARL4D. Interaction with phosphoinositides is required for plasma membrane targeting (PubMed:17398095).
In differentiating neuroblastoma cells, colocalizes with CCDC120 in neurite shaft and growth cone areas.
배경 (Background)
The protein encoded by this gene belongs to the PSCD family, characterized by:
- N-terminal coiled-coil motif: involved in homodimerization
- Central Sec7 domain: provides guanine-nucleotide exchange protein (GEP) activity
- C-terminal pleckstrin homology (PH) domain: interacts with phospholipids and mediates membrane association
Members of this family regulate protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6, and shares 83% homology with CYTH1. Two transcript variants encoding different isoforms have been identified.
[Provided by RefSeq, Aug 2008]
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