ELK Biotechnology Desmoplakin (phospho-Ser165/166) rabbit pAb

제품명

Desmoplakin (phospho-Ser165/166) rabbit pAb

대체 명칭

Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen)

적용 분야

• Western Blot (WB)

권장 희석 배율

• WB: 1:1000–2000

면역원

Synthesized phospho peptide around human Desmoplakin (Ser165 and 166)

저장 조건

• 종: Rabbit
• 보관: -20°C / 1년

클론 특성

• Clonality: Polyclonal
• Isotype: IgG
• 농도: 1 mg/ml

관찰 밴드

• 300 kDa

유전자 정보

세포 내 위치

Cell junction, desmosome. Cytoplasm, cytoskeleton. Cell membrane. Innermost portion of the desmosomal plaque.
Colocalizes with epidermal KRT5-KRT14 and simple KRT8-KRT18 keratins and VIM intermediate filaments network (PubMed:12802069).
Localizes at the intercalated disk in cardiomyocytes (By similarity).

배경 정보

This gene encodes a protein that anchors intermediate filaments to desmosomal plaques and forms an obligate component of functional desmosomes.
Mutations in this gene are the cause of several cardiomyopathies and keratodermas, including skin fragility-woolly hair syndrome.
Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

반응 종

Human, Mouse, Rat