ELK Biotechnology DGCR8 rabbit pAb
DGCR8 단백질을 인식하는 토끼 폴리클로날 항체로, WB에서 사용 가능. 인간 및 마우스 시료에 반응하며, 핵 및 핵소체에 주로 발현. Drosha 복합체 관련 miRNA 생합성 연구에 적합. -20°C에서 1년 보관 가능.
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제품명
DGCR8 rabbit pAb
제품 설명
DGCR8 단백질을 인식하는 토끼 폴리클로날 항체입니다. 이 항체는 Microprocessor complex의 비촉매적 서브유닛인 DGCR8을 표적하며, miRNA 생합성 연구에 유용합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | DGCR8 rabbit pAb |
| Alternative Names | Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8) |
| Applications | WB |
| Recommended Dilutions | WB 1:500–2000 |
| Immunogen | Synthesized peptide derived from human DGCR8 (AA range: 467–517) |
| Host Species | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 85 kD |
| Gene ID (Human) | 54487 |
| Human Swiss-Prot No | Q8WYQ5 |
| Species Reactivity | Human, Mouse |
| Cellular Localization | Nucleus, nucleolus. Colocalizes with nucleolin and DROSHA in the nucleolus. Mostly detected in the nucleolus as electron-dense granular patches around the fibrillar center (FC) and granular component (GC). Also detected in the nucleoplasm as small foci adjacent to splicing speckles near the chromatin structure. Localized with DROSHA in GW bodies (GWBs), also known as P-bodies (PubMed:17159994). |
Background
This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. (Provided by RefSeq, Jun 2010)
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