ELK Biotechnology Doublecortin (phospho-Ser297) rabbit pAb
Doublecortin (phospho-Ser297) rabbit pAb는 신경세포 이동 관련 단백질 Doublecortin의 인산화 형태를 검출하는 항체입니다. WB에 적합하며 인간과 랫트 시료에서 반응합니다. 미세소관 안정성과 신경 발달 연구에 활용됩니다.
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Doublecortin (phospho-Ser297) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | Doublecortin (phospho-Ser297) rabbit pAb |
| Alternative Names | Neuronal migration protein doublecortin (Doublin), Lissencephalin-X (Lis-X) |
| Applications | WB |
| Recommended Dilutions | WB 1:1000–2000 |
| Immunogen | Synthesized phospho peptide around human Doublecortin (Ser297) |
| Species Reactivity | Human, Rat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 44 kD |
| Gene ID (Human) | 1641 |
| Human Swiss-Prot No | O43602 |
| Cellular Localization | Cytoplasm; Cell projection, neuron projection; Localizes at neurite tips |
| Storage | -20°C / 1 year |
| Host | Rabbit |
Background
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain").
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