Thermo Fisher Scientific Gemin 5 Polyclonal Antibody
Gemin 5 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 적합하며 인간 시료에 반응. 항원 친화 크로마토그래피로 정제된 액상 제품으로 안정적인 저장 및 높은 특이성 제공.
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- PA557935
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- pk
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Thermo Fisher Scientific Gemin 5 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human Gemin 5. Recombinant protein control fragment (Product #RP-96859). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2641954 |
Product Specific Information
Immunogen sequence:
YDSGSFTIMQ EVYSAFLPDG CDHLRDKLGD HQSPATPAFK SLEAFFLYGR LYEFWWSLSR PCPNSSVWVR AGHRTLSVEP SQQLDTASTE ETDPET
Highest antigen sequence identity to the following orthologs:
- Mouse: 60%
- Rat: 59%
Target Information
The SMN complex plays a catalytic role in the assembly of small nuclear ribonucleoproteins (snRNPs), which are essential components of the spliceosome. It is crucial for the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins (SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG) that form a heptameric ring on the Sm site of small nuclear RNA. In the cytosol, these Sm proteins are held in an inactive 6S pICln-Sm complex by the chaperone CLNS1A. The SMN complex dissociates CLNS1A and facilitates the assembly of core snRNPs, which are then transported to the nucleus. GEMIN5 acts as the snRNA-binding protein within the SMN complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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