Thermo Fisher Scientific TLR1 Polyclonal Antibody
TLR1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ELISA, IP 등 다양한 실험에 사용 가능. 고순도 Affinity chromatography로 정제되었으며, 인간·마우스·랫트 반응성. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 200–250 on mouse toll-like receptor 1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TLR1 protein is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) expressed on infectious agents and mediate cytokine production necessary for effective immunity.
The TLR family in mammals consists of transmembrane proteins with leucine-rich repeats in the extracellular domain and an IL-1 receptor motif in the cytoplasmic domain. TLRs are an essential component of innate immunity in humans. In mice, TLR1 interacts with TLR2, and their co-expression enhances NF-kappaB activation in response to synthetic lipopeptides. They recognize lipid configurations of native mycobacterial lipoproteins and several tri-acylated lipopeptides. Different transcript lengths may result from alternative polyadenylation or splicing of the TLR1 gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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