Thermo Fisher Scientific AHNAK Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human AHNAK. Recombinant protein control fragment (Product #RP-92505). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:AHNAK,uniProtId:Q09666-1,ncbiNodeId:9606,antigenRange:483-614,antigenLength:5890,antigenImageFileName:PA5-55363_AHNAK_Q09666-1_Rabbit.svg,antigenImageFileNamePDP:PA5-55363_AHNAK_Q09666-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2637785

Product Specific Information

Immunogen sequence: MKGTKVKTPE MIIQKPKISM QDVDLSLGSP KLKGDIKVSA PGVQGDVKGP QVALKGSRVD IETPNLEGTL TGPRLGSPSG KTGTCRISMS EVDLNVAAPK VKGGVDVTLP RVEGKVKVPE VDVRGPKVDV SA

Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 82%.

Target Information

AHNAK1 (Desmoyokin) is a large (700 kDa) scaffold protein that translocates to the plasma membrane after an increas of extracellular calcium level or upon proteinkinase C activation and regulates extracellular calcium influx mediated by L-type Ca2+ channels. AHNAK1 has been implicated in diverse signal transduction proceses affecting cell differentiation and proliferation. In response to calcium-dependent intercellular contacts AHNAK1 forms multimeric complexes in the plasma membrane, connected with actin and annexin 2/S100A10 assemblies and is thus involved in organization of the plasma membrane architecture. In epithelial cells, AHNAK1 is localized in cytoplasm or is membrane-associated, but in cells of nonepithelial origin AHNAK1 is predominantly nuclear; it has a weak DNA-binding activity and associates with the DNA-ligase IV-XRCC4 complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.