Thermo Fisher Scientific TIM17 Polyclonal Antibody
Human TIM17 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 IHC(Paraffin) 실험에 적합. 항원 친화 크로마토그래피로 정제되었으며 PBS/BSA/glycerol 버퍼에 보관. 다양한 종에서 예측 반응성 확인됨. 연구용으로만 사용.
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Thermo Fisher Scientific TIM17 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–171 of Human TIM17 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.86 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547859 |
Product Specific Information
- Recommended positive control: K562
- Predicted reactivity: Mouse (94%), Rat (95%), Zebrafish (85%), Xenopus laevis (82%), Chicken (93%), Rhesus Monkey (99%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Translocation of nuclear encoded preproteins into the mitochondrial matrix requires the coordinated action of the translocases Tom and Tim, located in the outer and inner mitochondrial membranes respectively.
The Tom complex consists of multiple subunits including import receptors (Tom70, Tom37, Tom22, Tom20) and structural proteins (Tom40, Tom7, Tom6, Tom5).
The TIM channel imports nuclear-encoded mitochondrial preproteins and involves Tim17, Tim23, and Tim44.
Tim17 exists as two isoforms (Tim17a and Tim17b) differing in their C-terminal sequences and, along with Tim23, forms the structural elements of the inner membrane channel. Tim44 is a hydrophilic protein that recruits matrix Hsp70 to the translocation site.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: PA5-30385_TIM17_Q99595-1_Rabbit.svg / PA5-30385_TIM17_Q99595-1_Rabbit_PDP.jpeg)
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