Thermo Fisher Scientific NALP7 Polyclonal Antibody
Human NALP7 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot과 ELISA에 적합하며, 고순도 Affinity Chromatography 정제. 액상 형태로 -20°C 보관, 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 800–1000 of human NLRP7 (NP_6319152) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.24 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804724 |
Product Specific Information
Immunogen sequence:
CRLTEASCKD LAAVLVVSKK LTHLCLAKNP IGDTGVKFLC EGLSYPDCKL QTLVLQQCSI TKLGCRYLSE ALQEACSLTN LDLSINQIAR GLWILCQALE NPNCNLKHLR LWSCSLMPFY CQHLGSALLS NQKLETLDLG QNHLWKSGII KLFGVLRQRT GSLKILRLKT YETNLEIKKL LEEVKEKNPK LTIDCNASGA T
Positive Samples: HeLa, U-87MG, 293T, Jurkat, Mouse brain
Target Information
NOD proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins.
NALP7, also known as PYPAF3, is a member of the PYRIN-containing APAF1-like proteins (PYPAFs/NALPs) and plays a crucial role in cell proliferation.
It has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD), followed by a NACHT domain and a NACHT-associated domain.
NALP7 is expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. It inhibits caspase-1-dependent interleukin-1β secretion and acts as a feedback regulator.
Defects in the NALP7 gene are associated with hydatidiform mole (HYDM) formation and reduced carcinoma cell line growth.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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