Thermo Fisher Scientific NALP7 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 800-1000 of human NLRP7 (NP_6319152) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NALP7,uniProtId:Q8WX94-2,ncbiNodeId:9606,antigenRange:800-1000,antigenLength:1009,antigenImageFileName:PA5-88184_NALP7_Q8WX94-2_Rabbit.svg,antigenImageFileNamePDP:PA5-88184_NALP7_Q8WX94-2_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.24 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804724

Product Specific Information

Immunogen sequence: CRLTEASCKD LAAVLVVSKK LTHLCLAKNP IGDTGVKFLC EGLSYPDCKL QTLVLQQCSI TKLGCRYLSE ALQEACSLTN LDLSINQIAR GLWILCQALE NPNCNLKHLR LWSCSLMPFY CQHLGSALLS NQKLETLDLG QNHLWKSGII KLFGVLRQRT GSLKILRLKT YETNLEIKKL LEEVKEKNPK LTIDCNASGA T; Positive Samples: HeLa, U-87MG, 293T, Jurkat, Mouse brain

Target Information

NOD proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins. NALP7, also known as PYPAF3, a member of the related PYRIN-containing APAF1-like proteins (PYPAFs/NALPs) is thought to play a crucial role in cell proliferation. NALP7 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It is expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. NALP7 inhibits caspase-1-dependent interleukin-1-b secretion and is a feedback regulator of interleukin-1-b secretion. Defects in the NALP7 gene are known to cause the formation of a hydatidiform mole (HYDM) and reduce the growth of carcinoma cell lines.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.