Thermo Fisher Scientific NAT1 Polyclonal Antibody
Thermo Fisher Scientific의 NAT1 Polyclonal Antibody는 인간 NAT1 단백질을 인식하는 토끼 다클론 항체입니다. IHC(P)에서 1:2,500–1:5,000 희석으로 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 약물 대사 및 해독 연구에 적합합니다.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:2,500–1:5,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human NAT1. Recombinant protein control fragment (Product #RP-99582) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.7 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2644480 |
Product Specific Information
Immunogen sequence:
SRNKLDLETL TDILQHQIRA VPFENLN
Sequence identity:
- Mouse: 85%
- Rat: 89%
Target Information
Arylamine N-acetyltransferases (NAT-1 and NAT-2) catalyze N- or O-acetylation of heterocyclic and arylamine substrates in the detoxification of a wide array of drugs. Certain alleles causing high N-acetyltransferase activity have been associated with colon and urinary bladder cancers, as NATs also bioactivate several known carcinogens. Both NAT-1 and NAT-2 are cytoplasmic proteins and play an active role in the detoxification of many arylamine and hydrazine drugs. N-acetylation polymorphism is determined by the level of NAT activity in liver tissues, and has been linked to the action and toxicity of drugs that contain amines. Human NAT-1 is the functional homolog of rodent NAT-2, while human NAT-2 is the functional homolog of rodent NAT-1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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