Thermo Fisher Scientific CENPE Polyclonal Antibody
CENPE 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 사용 가능하며, 인체 유래 항원으로 제작됨. 고순도 친화 크로마토그래피 정제, PBS/glycerol buffer로 안정화된 액상 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CENPE (Accession Q02224), corresponding to amino acid residues F2661–Q2701 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852281 |
Product Specific Information
This antibody detects endogenous levels of total CENPE.
Target Information
14-3-3 sigma (stratifin, SFN, epithelial cell marker protein 1) is a member of a highly conserved family of 14-3-3 proteins present in all eukaryotic organisms. Seven mammalian isoforms (epsilon, beta, zeta, gamma, theta, tau, and sigma) play key roles in biological processes by binding and altering subcellular localization or stability of signaling molecules.
14-3-3 sigma was first identified as a mammary epithelium marker and later recognized as a regulator of the cell cycle checkpoint. It may serve as a prognostic marker for pancreatic cancer treatment outcomes.
This isoform is uniquely induced by p53 in response to DNA damage and functions as a p53-regulated inhibitor of G2/M progression, acting as a tumor suppressor gene often inactivated by methylation in epithelial tumor cells.
Two human 14-3-3 sigma isoforms are produced by alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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