Thermo Fisher Scientific Factor I light chain Polyclonal Antibody
Thermo Fisher Scientific의 Factor I light chain Polyclonal Antibody는 인간, 마우스, 랫트 반응성을 가지며 다양한 면역학적 분석(WB, IHC, ICC, ELISA)에 사용 가능합니다. 단백질 A로 정제된 고품질 항체로, 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Factor I Complement factor I light chain, amino acids 281–380 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The complement pathway is a crucial host defense system contributing to both innate and acquired immunity. There are three activation pathways: classical, lectin, and alternative. Complement protein Factor I is a key serine protease regulating the complement cascade by controlling C3 convertase levels. It circulates in plasma as a heavily N-glycosylated heterodimer composed of two disulfide-linked chains, each with three N-linked oligosaccharide chains that play structural and functional roles during catalysis. Factor I specifically cleaves C3b and C4b, requiring cofactors such as Factor H, CR1, or MCP for C3b cleavage, and C4bp or CR1 for C4b cleavage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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