Thermo Fisher Scientific Mel-18 Polyclonal Antibody
Mel-18 단백질을 표적으로 하는 Rabbit Polyclonal Antibody로 인간 시료에 반응합니다. Western blot 및 Immunoprecipitation에 적합하며 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 4°C에서 보관합니다. 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 125 and 175 of human DNA-binding Protein Mel-18 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
Target Information
The protein encoded by this gene contains a RING finger motif and is similar to polycomb group (PcG) gene products. PcG proteins form complexes via protein-protein interactions and maintain transcriptional repression of genes involved in embryogenesis, cell cycle, and tumorigenesis.
Mel-18 acts as a negative regulator of transcription and has tumor suppressor activity. Expression is detected in various tumor cells but limited in neural organs in normal tissues. Knockout studies in mice suggest that Mel-18 negatively regulates cytokine and chemokine expression, playing a role in lymphocyte differentiation, migration, and immune response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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