Thermo Fisher Scientific CKMT1B Monoclonal Antibody (2C9)
Human CKMT1B 단백질을 인식하는 Mouse monoclonal antibody(2C9)로 Western blot과 ELISA에 적합. GST-tagged recombinant protein을 면역원으로 사용. PBS buffer, no preservative, -20°C 보관. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 0.1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2C9 |
| Immunogen | CKMT1B (NP_066270, 327–417 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein Sequence:
GVHIKLPLLS KDSRFPKILE NLRLQKRGTG GVDTAATGGV FDISNLDRLG KSEVELVQLV IDGVNYLIDC ERRLERGQDI RIPTPVIHTK H
Target Information
Mitochondrial creatine kinase (MtCK) is responsible for transferring high-energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family and exists as two isoenzymes: sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes.
Mitochondrial creatine kinase forms dimers and octamers, unlike cytosolic creatine kinase, which is only dimeric. Overexpression of ubiquitous mitochondrial creatine kinase has been observed in various malignant cancers with poor prognosis, potentially linked to high energy turnover and apoptosis resistance. Two genes on chromosome 15 encode identical mitochondrial creatine kinase proteins with 80% homology to the sarcomeric isoform.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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