Thermo Fisher Scientific DBF4A Polyclonal Antibody
DBF4A 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC, ELISA 등에 사용 가능. Human, Mouse, Rat 반응성. Protein A로 정제된 액상 형태이며, -20°C에서 보관. 세포주기 G1/S 전환 관련 연구에 적합.
- 카탈로그번호
- BS-7895R
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human DBF4A (amino acids 21–110) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Activator of S phase kinase (ASK, DBF4) is a regulatory subunit of the human Cdc7 kinase complex that plays a key role in the G1/S cell cycle transition in mammalian cells. The increase in Cdc7 kinase activity at the G1/S boundary is partly due to elevated ASK expression in late G1. ASK interacts with replication origins, suggesting that Cdc7 may trigger S phase by activating replication initiation complexes at these origins. Human ASK levels fluctuate during the cell cycle, paralleling Cdc7 kinase activity. The Cdc7-ASK complex regulates DNA replication initiation by targeting MCM2 protein. ASK contains nuclear localization signals and may require additional signals for chromatin binding, which increases at late G1. A functional link may exist between menin (a tumor suppressor mutated in MEN1) and ASK in regulating cell proliferation.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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