Thermo Fisher Scientific DBF4A Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

Activator of S phase kinase (ASK, DBF4) is a regulatory subunit of the human Cdc7 kinase complex that plays a key role in the G1/S cell cycle transition in mammalian cells. The increase in Cdc7 kinase activity at the G1/S boundary is partly due to elevated ASK expression in late G1. ASK interacts with replication origins, suggesting that Cdc7 may trigger S phase by activating replication initiation complexes at these origins. Human ASK levels fluctuate during the cell cycle, paralleling Cdc7 kinase activity. The Cdc7-ASK complex regulates DNA replication initiation by targeting MCM2 protein. ASK contains nuclear localization signals and may require additional signals for chromatin binding, which increases at late G1. A functional link may exist between menin (a tumor suppressor mutated in MEN1) and ASK in regulating cell proliferation.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.