Thermo Fisher Scientific TRIM56 Monoclonal Antibody (4C5)
TRIM56 단백질을 인식하는 Mouse monoclonal antibody(4C5)로, Western blot, ICC/IF, ELISA에 적합합니다. 인간 시료에 반응하며, PBS buffer에 보존된 액상 형태입니다. 항바이러스 면역 관련 연구용으로 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4C5 |
| Immunogen | TRIM56 (NP_112223, 656–755 a.a.) partial recombinant protein with GST tag (26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein Sequence:
NSVVICDGLG QVVGEYKGPG LHGCQPGSVS VDKKGYIFLT LREVNKVVIL DPKGSLLGDF LTAYHGLEKP RVTTMVDGRY LVVSLSNGTI HIFRVRSPDS
Target Information
E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118).
In response to pathogen- and host-derived double-stranded DNA (dsDNA), TRIM56 targets STING1 to Lys-63-linked ubiquitination, promoting its homodimerization, a step required for IFN-beta production.
Independently of its E3 ubiquitin ligase activity, TRIM56 positively regulates TLR3 signaling and enhances dsRNA-induced expression of IFNB1 and interferon-stimulated genes (ISG15, IFIT1/ISG56, CXCL10, OASL, CCL5/RANTES).
Promotes antiviral state establishment and chemokine induction following hepatitis C virus infection (PubMed:22948160).
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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