Thermo Fisher Scientific CLDN4 Monoclonal Antibody (4A11)
인간 Claudin-4 단백질을 인식하는 마우스 단클론 항체. ELISA 및 IP에 사용 가능하며, 고순도의 친화 크로마토그래피 정제 제품. PBS(pH 7.4) 용액 형태로 제공되며 방부제 무첨가. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| ELISA | 1 ng/mL |
| Immunoprecipitation (IP) | 1–5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG3, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4A11 |
| Immunogen | CLDN4 (NP_001296, 29–78 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein:
MWRVTAFIGS NIVTSQTIWE GLWMNCVVQS TGQMQCKVYD SLLALPQDLQ
Target Information
Claudin-4 belongs to the 20-member family of claudins, transmembrane cellular adhesion proteins localized at epithelial and endothelial tight junctions. Claudins demonstrate distinct, tissue-specific expression patterns and are essential components of tight junction charge-specific channels that regulate paracellular ion flux.
Claudin-4 is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. Overexpression of Claudin-4 decreases paracellular electrical conductance due to selective reduction in Na⁺ permeability, with no significant change in Cl⁻ permeability. In ovarian carcinoma cells, Claudin-3 and Claudin-4 are upregulated at both mRNA and protein levels. Claudin-4 is also overexpressed in pancreatic and other epithelial cancers. The Claudin-4 gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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