
Thermo Fisher Scientific FKBP12 Monoclonal Antibody (OTI3B3)
FKBP12 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, Western Blot, IHC, ICC/IF, Flow Cytometry에 사용 가능. 인간 반응성, Mouse IgG2b 아이소타입. 액상 형태로 1 mg/mL 농도, -20°C 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3B3 |
| Immunogen | Full length human recombinant protein of FKBP1A produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2723184 |
Target Information
FKBP12 is a member of the immunophilin protein family, involved in immunoregulation and cellular processes such as protein folding and trafficking. It acts as a cis-trans prolyl isomerase binding FK506 and rapamycin, and interacts with intracellular signal transduction proteins including type I TGF-beta receptor. FKBP12 also associates with intracellular calcium release channels and coordinates multi-protein complex formation of the skeletal muscle ryanodine receptor. In mice, deletion of the homologous gene leads to congenital heart disorder known as noncompaction of left ventricular myocardium.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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