Thermo Fisher Scientific TNFSF8 Monoclonal Antibody (2E11)
Human TNFSF8 단백질을 인식하는 Mouse IgM 단클론 항체로, Western blot 및 ELISA에 적합합니다. CD30/CD153 상호작용 연구에 유용하며, 세포 활성화·분화·사멸 관련 연구에 활용됩니다. 액상 형태로 제공되며, -20°C에서 보관합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgM, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2E11 |
| Immunogen | TNFSF8 (NP_001235, 153 a.a.–approximately 234 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
NNSVDLKLEL LINKHIKKQA LVTVCESGMQ TKHVYQNLSQ FLLDYLQVNT TISVNVDTFQ YIDTSTFPLE NVLSIFLYSN SD
Target Information
The ligand for CD30 is CD30L (CD153). The binding of CD30 to CD30L mediates pleiotropic effects including cell proliferation, activation, differentiation, and apoptotic cell death. CD30 plays a critical role in the pathophysiology of Hodgkin’s disease and other CD30⁺ lymphomas. It acts as a costimulatory molecule in thymic negative selection.
CD30 expression is observed on Hodgkin’s and Reed-Sternberg cells, some non-Hodgkin’s lymphomas (including Burkitt’s lymphoma), virus-infected T and B cells, and on activated normal T and B cells. In T cells, CD30 is expressed on subsets producing Th2-type cytokines and on CD4⁺/CD8⁺ thymocytes coexpressing CD45RO and the IL4 receptor.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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