Thermo Fisher Scientific RPGR Polyclonal Antibody
Human RPGR 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:50–1:200 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol 버퍼에 보관. 시각 수용체 연구 및 X-linked retinitis pigmentosa 관련 연구에 적합.
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- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human RPGR. Recombinant protein control fragment (Product # RP-92146) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2646715 |
Product Specific Information
Immunogen sequence:
EINDTCLSVA TFLPYSSLTS GNVLQRTLSA RMRRRERERS PDSFSMRRTL PPIEGTLGLS ACFLPNSVFP RCSERNLQES VLSEQDLMQP EEPDYLLDEM TKEAEIDNSS TVESLGETTD ILNMTHIMSL N
- Highest antigen sequence identity to the following orthologs:
- Mouse: 46%
- Rat: 41%
Target Information
This gene encodes a protein with a series of six RCC1-like domains (RLDs), characteristic of the highly conserved guanine nucleotide exchange factors.
The encoded protein is found in the Golgi body and interacts with RPGRIP1.
This protein localizes to the outer segment of rod photoreceptors and is essential for their viability.
Mutations in this gene have been associated with X-linked retinitis pigmentosa (XLRP).
Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length natures of only some have been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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