Thermo Fisher Scientific S100B Recombinant Mouse Monoclonal Antibody (rS100B, 1896)
Recombinant mouse monoclonal antibody against S100B protein. Validated for WB, IHC, and peptide array applications. High purity (Protein A/G purified) and unconjugated form. Suitable for research on neurodegenerative and cancer-related pathways.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | rS100B, 1896 |
| Immunogen | Recombinant full-length human S100B protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For immunohistochemistry (PFA-fixed): incubate antibody for 30 min at room temperature (RT).
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, followed by cooling at RT for 20 min.
Target Information
S100B is a member of the S100 family of proteins containing two EF-hand calcium-binding motifs. These proteins are localized in the cytoplasm and/or nucleus of various cells and regulate cellular processes such as cell cycle progression and differentiation.
S100B may function in neurite extension, melanoma cell proliferation, stimulation of Ca²⁺ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis, axonal proliferation, and inhibition of microtubule assembly.
Chromosomal rearrangements and altered expression of S100B have been linked to diseases including Alzheimer’s disease, Down’s syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: 6285-MSM6-P1ABX_S100B_P04271-1_House_mouse.svg, 6285-MSM6-P1ABX_S100B_P04271-1_House_mouse_PDP.jpeg)
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배송/결제/교환/반품 안내
배송 정보
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