Thermo Fisher Scientific CHIT1 Monoclonal Antibody (1D11)
인간 CHIT1 단백질을 인식하는 Mouse IgG1 단일클론 항체. Western blot과 ELISA에 적합하며, 친화 크로마토그래피로 정제됨. 보존제 무첨가 PBS 용액 형태로 제공되며, 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 0.03 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1D11 |
| Immunogen | CHIT1 (NP_003456.1, 60 a.a. approximately 169 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
GMTNHQLSTT EWNDETLYQE FNGLKKMNPK LKTLLAIGGW NFGTQKFTDM VATANNRQTF VNSAIRFLRK YSFDGLDLDW EYPGSQGSPA VDKERFTTLV QDLANAFQQE
Target Information
Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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