Thermo Fisher Scientific CHIT1 Monoclonal Antibody (1D11)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

-

ELISA (ELISA)

0.03 ng/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

1D11

Immunogen

CHIT1 (NP_003456.1, 60 a.a. approximately 169 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Chitotriosidase,uniProtId:Q13231-1,ncbiNodeId:9606,antigenRange:60-169,antigenLength:466,antigenImageFileName:H00001118-M01_Chitotriosidase_Q13231-1_House_mouse.svg,antigenImageFileNamePDP:H00001118-M01_Chitotriosidase_Q13231-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: GMTNHQLSTT EWNDETLYQE FNGLKKMNPK LKTLLAIGGW NFGTQKFTDM VATANNRQTF VNSAIRFLRK YSFDGLDLDW EYPGSQGSPA VDKERFTTLV QDLANAFQQE

Target Information

Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.