Thermo Fisher Scientific Mouse Noggin, Animal-Free Recombinant Protein, PeproTech
동물 유래 성분이 없는 Mouse Noggin 재조합 단백질로, BMP-4 유도 활성 억제 평가에 사용됩니다. E. coli 발현 시스템에서 생산되며, ≥98%의 고순도와 낮은 엔도톡신 수준(<0.1 EU/µg)을 보장합니다. 발달 및 골형성 연구용으로 적합합니다.
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Applications
Functional Assay (Functional)
- Assay-dependent
In vitro Assay (IV)
- Refer to publications (9 available)
Miscellaneous PubMed (Misc)
- Refer to publication (1 available)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Mouse |
| Published species | Human, Mouse |
| Expression System | E. coli |
| Amino Acid Sequence | MQHYLHIRPA PSDNLPLVDL IEHPDPIFDP KEKDLNETLL RSLLGGHYDP GFMATSPPED RPGGGGGPAG GAEDLAELDQ LLRQRPSGAM PSEIKGLEFS EGLAQGKKQR LSKKLRRKLQ MWLWSQTFCP VLYAWNDLGS RFWPRYVKVG SCFSKRSCSV PEGMVCKPSK SVHLTVLRWR CQRRGGQRCG WIPIQYPIIS ECKCSC |
| Molecular Weight | 46.4 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥98% (SDS-PAGE, HPLC) |
| Endotoxin Concentration | <0.1 EU/µg |
| Activity | Inhibits 5.0 ng/ml BMP-4 induced alkaline phosphatase production in ATDC5 cells. Expected ED50: 1.0–2.0 ng/ml. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
- AF-250-38-1MG is provided as 2 × 500 µg (AF-250-38-500UG).
- Recombinant murine Noggin is a 46.4 kDa disulfide-linked homodimer, consisting of two 206 amino acid polypeptide chains.
- Shipped at ambient temperature.
- For storage, handling, and reconstitution, refer to the lot-specific Certificate of Analysis.
Target Information
Noggin plays a key role in developmental processes such as neural tube fusion and joint formation. Organ morphogenesis begins with epithelial stem cell downgrowth, regulated by WNT3A (β-catenin stabilization) and Noggin, a BMP inhibitor. Mutations in Noggin are associated with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1), both characterized by joint fusion defects.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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