Thermo Fisher Scientific EMR1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human EMR1 for WB, IHC, and Flow Cytometry. High specificity and sensitivity with 1 mg/mL concentration. Suitable for macrophage marker studies. For research use only.
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Thermo Fisher Scientific EMR1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human EMR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
Target Information
F4/80 antigen is a 160 kDa cell surface glycoprotein that belongs to the EGF TM7 family of proteins and shares 68% overall amino acid identity with human EGF module-containing mucin-like hormone receptor 1 (EMR1). Expression of F4/80 is heterogeneous and varies during macrophage maturation and activation.
The F4/80 antigen is expressed on a wide range of mature tissue macrophages including:
- Kupffer cells
- Langerhans cells
- Microglia
- Macrophages in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma
- Macrophages in the red pulp of the spleen
F4/80 expression has also been observed on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of the spleen and lymph node. Although the ligands and biological functions of the F4/80 antigen have not yet been fully determined, recent studies suggest a role for F4/80 in the generation of efferent CD8+ regulatory T cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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