Thermo Fisher Scientific NOXA Polyclonal Antibody
인간 NOXA 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunocytochemistry에 사용 가능. 친화 크로마토그래피로 정제된 액상 항체이며, PBS/glycerol buffer에 보관. p53 경로 관련 세포사멸 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PMAIP1 (Accession Q13794), corresponding to amino acid residues M1–G33 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850151 |
Product Specific Information
Antibody detects endogenous levels of total NOXA.
Target Information
Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA.
A new p53 target gene, Noxa, encodes a protein belonging to the subfamily of BH3-only proapoptotic proteins. Noxa and PUMA are both transcriptional targets of p53 and BH3-only proteins.
X-ray irradiation increases p53-dependent Noxa mRNA and protein levels. When ectopically expressed, Noxa interacts with anti-apoptotic Bcl-2 family members, resulting in activation of caspase-9.
Like PUMA, Noxa localizes to mitochondria and induces apoptosis in response to p53. Noxa and PUMA may represent direct mediators of p53-induced apoptosis. Increased levels of p53 and its target gene Noxa are found in impaired tumor development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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