Thermo Fisher Scientific Apolipoprotein B Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:2,000
• View 1 publication

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total APOB.

Target Information

Apolipoprotein B (apo B) is a major protein of low-density lipoproteins (LDL) in human plasma, with a molecular mass of approximately 260–500 kDa.
It binds to specific cell membrane receptors and is involved in the removal of LDL and very low-density lipoprotein (VLDL) cholesterol from circulation.

LDL acts as the carrier protein for cholesterol in the blood. Oxidatively modified LDL is found in atherosclerotic lesions and is recognized by macrophages via scavenger receptor A and CD36.
Elevated levels of Apolipoprotein B are associated with premature atherosclerosis. Normal plasma levels are around 800 mg/L.

Apolipoprotein B occurs as two main isoforms, apoB-48 and apoB-100, encoded by a single gene. ApoB-48 is produced after RNA editing of the apoB-100 transcript, leading to early translation termination.
Mutations in the Apolipoprotein B gene or its regulatory region can cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective Apolipoprotein B.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

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