Thermo Fisher Scientific Apolipoprotein B Polyclonal Antibody
Thermo Fisher Scientific의 Apolipoprotein B Polyclonal Antibody는 인간 및 마우스 시료에 반응하며 Western blot에 적합합니다. Rabbit IgG 폴리클로날 항체로, 인간 APOB 유래 합성 펩타이드로 면역화되었습니다. 액상 형태로 1 mg/mL 농도이며 PBS + 50% glycerol 저장 버퍼를 포함합니다.
- 카탈로그번호
- PA5114864
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB): 1:500–1:2,000
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human APOB (Accession P04114), corresponding to amino acid residues K3973–N4023 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899500 |
Product Specific Information
Antibody detects endogenous levels of total APOB.
Target Information
Apolipoprotein B (apo B) is a major protein of low-density lipoproteins (LDL) in human plasma, with a molecular mass of approximately 260–500 kDa.
It binds to specific cell membrane receptors and is involved in the removal of LDL and very low-density lipoprotein (VLDL) cholesterol from circulation.
LDL acts as the carrier protein for cholesterol in the blood. Oxidatively modified LDL is found in atherosclerotic lesions and is recognized by macrophages via scavenger receptor A and CD36.
Elevated levels of Apolipoprotein B are associated with premature atherosclerosis. Normal plasma levels are around 800 mg/L.
Apolipoprotein B occurs as two main isoforms, apoB-48 and apoB-100, encoded by a single gene. ApoB-48 is produced after RNA editing of the apoB-100 transcript, leading to early translation termination.
Mutations in the Apolipoprotein B gene or its regulatory region can cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective Apolipoprotein B.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(PA5-114864_Apolipoprotein_B_P04114-1_Rabbit.svg)
(PA5-114864_Apolipoprotein_B_P04114-1_Rabbit_PDP.jpeg)
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