Thermo Fisher Scientific MYZAP Polyclonal Antibody
인간 MYZAP 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 1:200–1:500 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. 심근 및 폐 조직 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MYZAP. Recombinant protein control fragment (Product #RP-98067) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2644404 |
Product Specific Information
Immunogen sequence:
TVPPESPVPE QCEKKIERKE QLLDLSNGEP TRKLPQGVVY GVVRRSDQNQ QKEMVVYGWS TSQLKEEMNY IKDVRATLEK VRKRMYGDYD EM
Sequence identity:
Highest antigen sequence identity to the following orthologs:
- Mouse: 87%
- Rat: 88%
Target Information
MYOZAP (also known as GRINL1A) is a 54 kDa highly conserved cardiac protein strongly expressed in the heart and lung. It is a novel component of the intercalated disc and interacts with myosin phosphatase-RhoA interacting protein (MRIP), acting as an activator of Rho-dependent SRF signaling. Knockdown studies in zebrafish result in cardiomyopathy with severe dysfunction. The MYOZAP gene is part of a complex transcript unit that includes the gene for glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A (GRINL1A). Transcription occurs at an upstream promoter, producing two groups of alternatively spliced variants: Gup (GRINL1A upstream transcripts) and Gcom (GRINL1A combined transcripts).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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