Thermo Fisher Scientific CD11b/c Monoclonal Antibody (OX-42), APC

Applications

• Flow Cytometry (Flow): Assay-dependent

Product Specifications

Target Information

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain.
CD11b is implicated in various adhesive interactions of monocytes, macrophages, and granulocytes, as well as in mediating the uptake of complement-coated particles. It is identical to CR3, the receptor for the iC3b fragment of the third complement component.
CD11b also acts as a receptor for fibrogen, factor X, and ICAM1, recognizing P1 and P2 peptides of the fibrogen gamma chain. The Mac1 CD11b antigen is present on macrophages, granulocytes, natural killer cells, and blood monocytes.
CD11b is expressed on 8% of spleen cells, 44% of bone marrow cells, and less than 1% of thymocytes, and is commonly used as a microglial marker in nervous tissue.
CD11c encodes the integrin alpha X chain protein, which combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4).
The alpha X beta 2 complex overlaps the properties of the alpha M beta 2 integrin in adherence of neutrophils and monocytes to stimulated endothelium cells and in the phagocytosis of complement-coated particles.
Mutations affecting the CD11b/c gene are associated with systemic lupus erythematosus 6.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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