Thermo Fisher Scientific NPRL2 Polyclonal Antibody
NPRL2 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. Western Blot에 최적화되어 있으며, 합성 펩타이드 항원을 사용해 제작되었습니다. 액상 형태로 -20°C에서 보관하며, 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human NPRL2 (UniProt ID: Q8WTW4-1, antigen range: 356–376, antigen length: 380) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2691687 |
Product Specific Information
Predicted to react with Mouse and Rat samples.
Target Information
NPRL2 (also known as TUSC4, tumor suppressor candidate 4) is a 380 amino acid protein containing a bipartite nuclear localization signal and a granulin protein-binding domain. It is highly expressed in skeletal muscle, followed by brain, liver, and pancreas, with lower expression in lung, kidney, placenta, and heart. NPRL2 is expressed in most lung cancer cell lines and may function as a tumor suppressor. It may participate in mismatch repair, cell cycle checkpoint signaling, and activation of apoptotic pathways. NPRL2 may also enhance the therapeutic efficacy of chemotherapy drugs such as cisplatin by resensitizing resistant patients. The gene encoding NPRL2 is conserved across species and expressed as two isoforms due to alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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