Thermo Fisher Scientific Laminin gamma-1 Recombinant Rabbit Monoclonal Antibody (23GB6415)

Applications

• Western Blot (WB): 1:1,000–1:5,000

Product Specifications

Target Information

Laminins are essential and abundant structural non-collagenous glycoproteins localized to basement membranes. These membranes, which are cell-associated extracellular matrices (ECMs), are composed of Laminins, Type IV Collagen networks, Nidogen, and various proteoglycans. They are found beneath epithelial layers, around blood vessel endothelium, and surrounding muscle, peripheral nerve, and fat cells.

Formation of basement membranes influences cell proliferation, phenotype, migration, gene expression, and tissue architecture. Each Laminin is a heterotrimer consisting of alpha, beta, and gamma chain subunits that are secreted and incorporated into the ECM. Laminins can self-assemble, bind to other matrix macromolecules, and interact with cells via Integrins, dystroglycan, and Laminin receptors. The human Laminin gamma-1 gene maps to chromosome 1q31 and is ubiquitously expressed in tissues that produce basement membranes.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.