Thermo Fisher Scientific LPIN3 Polyclonal Antibody
Thermo Fisher Scientific의 LPIN3 폴리클로날 항체는 인간 LPIN3 단백질을 인식하는 Rabbit IgG 항체로, 면역세포염색(ICC/IF)에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼와 글리세롤로 안정화되어 있습니다. 연구용으로만 사용 가능합니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human LPIN3. Recombinant protein control fragment (Product #RP-107757) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2664570 |
Product Specific Information
Immunogen sequence:
LIQELIKNHKS TYERLGEVVE LLFPPVARGP STDLANPEYS NFCYWREPLP AVDLDT
- Highest antigen sequence identity to the following orthologs:
- Mouse: 81%
- Rat: 89%
Target Information
Human lipodystrophy is characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. Mice carrying mutations in the fatty liver dystrophy gene have similar phenotypes. Through positional cloning, the mouse gene responsible for fatty liver dystrophy was isolated and designated Lpin1. The nuclear protein encoded by Lpin1 was named lipin.
Lpin1 mRNA was expressed at high levels in adipose tissue and was induced during differentiation of preadipocytes, indicating that lipin is required for normal adipose tissue development and is a candidate gene for human lipodystrophy.
Database searches identified mouse and human EST and genomic sequences similar to Lpin1, including two related mouse genes and three human homologs.
- Human LPIN1 gene: mapped to 2p25
- Human LPIN2: mapped to 18p11
- Human LPIN3: mapped to 20q11–q12
- Mouse Lpin1, Lpin2, Lpin3: mapped to chromosomes 12, 17, and 2, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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