Thermo Fisher Scientific SYNE1 Monoclonal Antibody (OTI9A11), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Product Specifications

Target Information

There are two genes encoding members of a new family of type II integral membrane proteins. Both are ubiquitously expressed, and tissue-specific alternative mRNA initiation and splicing generate at least two major isoforms of each protein, with the smaller isoforms being truncated at the N-terminus.

These proteins are called nesprin-1 and -2 for nuclear envelope spectrin repeat, as they are characterized by the presence of multiple clustered spectrin repeats, bipartite nuclear localization sequences, and a conserved C-terminal single transmembrane domain.

Transient transfection of EGFP-fusion expression constructs demonstrated their localization to the nuclear membrane with a novel C-terminal TM-domain-containing sequence essential for perinuclear localization. Nesprin-1 is developmentally regulated in both smooth and skeletal muscle and is relocalized from the nuclear envelope to the nucleus and cytoplasm during C2Cl2 myoblast differentiation.

Nesprins may function as “dystrophins of the nucleus” to maintain nuclear organization and structural integrity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.