Thermo Fisher Scientific NOC3L Polyclonal Antibody
NOC3L 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunocytochemistry에 적합합니다. 인간 및 생쥐 시료에 반응하며, 액상 형태로 제공됩니다. 친화 크로마토그래피로 정제되었으며, -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NOC3L (Accession Q8WTT2), corresponding to amino acid residues Y414–W464. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851164 |
Product Specific Information
Antibody detects endogenous levels of total NOC3L.
Target Information
GADD 153, a growth arrest and DNA damage-inducible gene, encodes a C/EBP-related nuclear protein. This protein has also been designated C/EBP-homologous protein (CHOP-10 or C/EBP zeta). GADD 153 expression is induced by various cellular stresses, including nutrient deprivation and metabolic perturbations. It functions to block cells in the G1 to S phase during cell cycle progression by dimerizing with other C/EBP proteins, redirecting dimers from classical to nonclassical binding sites. Thus, GADD 153 acts as a negative modulator of C/EBP-like proteins in certain terminally differentiated cells. GADD 153 belongs to the CBF/MAK21 family, which also includes NOC2L, NOC3L, and NOC4L. NOC3L, also known as factor for adipocyte differentiation 24 (Fad24), promotes adipogenesis by controlling DNA replication during the early stages of mitotic clonal expansion (MCE).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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