Thermo Fisher Scientific DMP1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

Dentin matrix acidic phosphoprotein (DMP1) is an extracellular matrix protein and a member of the small integrin-binding ligand N-linked glycoprotein family. It plays a critical role in the proper mineralization of bone and dentin and is expressed in various bone and tooth cells.

The protein contains multiple acidic domains, phosphorylation sites, a functional arg-gly-asp (RGD) cell attachment sequence, and a DNA-binding domain. In undifferentiated osteoblasts, DMP1 acts as a nuclear protein regulating osteoblast-specific gene expression. Upon osteoblast maturation, it becomes phosphorylated and exported to the extracellular matrix, where it orchestrates mineralized matrix formation.

Mutations in the DMP1 gene are associated with autosomal recessive hypophosphatemia, manifesting as rickets and osteomalacia. The gene structure is conserved among mammals, and two transcript variants encoding distinct isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.