Thermo Fisher Scientific DMP1 Polyclonal Antibody
DMP1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합. Human 시료 반응성. Protein A 정제 및 1 mg/mL 농도의 액상 형태로 제공. 골 및 치아 조직의 미네랄화 연구에 유용.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific DMP1 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human DMP1, amino acids 221–320 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Dentin matrix acidic phosphoprotein (DMP1) is an extracellular matrix protein and a member of the small integrin-binding ligand N-linked glycoprotein family. It plays a critical role in the proper mineralization of bone and dentin and is expressed in various bone and tooth cells.
The protein contains multiple acidic domains, phosphorylation sites, a functional arg-gly-asp (RGD) cell attachment sequence, and a DNA-binding domain. In undifferentiated osteoblasts, DMP1 acts as a nuclear protein regulating osteoblast-specific gene expression. Upon osteoblast maturation, it becomes phosphorylated and exported to the extracellular matrix, where it orchestrates mineralized matrix formation.
Mutations in the DMP1 gene are associated with autosomal recessive hypophosphatemia, manifesting as rickets and osteomalacia. The gene structure is conserved among mammals, and two transcript variants encoding distinct isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.