Thermo Fisher Scientific Human 4-1BB Ligand (TNFSF9), Animal-Free Recombinant Protein, PeproTech
동물 유래 성분이 없는 Human 4-1BB Ligand 재조합 단백질로, CD137/NF-kappaB 활성 유도 기능 검증됨. 높은 순도(≥98%)와 낮은 엔도톡신(<0.1 EU/µg)을 보유. 면역세포 활성 연구 및 T세포 자극 기전 분석에 적합. Thermo Fisher Scientific 공급.
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Applications
- Functional Assay (Functional)
Tested Dilution: Assay-dependent
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | E. coli |
| Amino Acid Sequence | MREGPELSPD DPAGLLDLRQ GMFAQLVAQN VLLIDGPLSW YSDPGLAGVS LTGGLSYKED TKELVVAKAG VYYVFFQLEL RRVVAGEGSG SVSLALHLQP LRSAAGAAAL ALTVDLPPAS SEARNSAFGF QGRLLHLSAG QRLGVHLHTE ARARHAWQLT QGATVLGLFR VTPEIPAGLP SPRSE |
| Molecular Weight | 19.5 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 98% by SDS-PAGE gel and HPLC analyses |
| Endotoxin Concentration | <0.1 EU/µg |
| Activity | Induces CD137/NF-kappaB activation in HEK293 reporter cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
Recombinant Human 4-1BB Ligand is a soluble 19.5 kDa protein consisting of 185 amino acid residues.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily.
It acts as a co-stimulatory molecule expressed on antigen-presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation.
Its receptor, CD137/4-1BB, is found on various cells, including inflamed endothelial cells, where its expression enhances extravasation of CD137L-expressing monocytes.
Activated T cells express CD137, and engagement with CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity.
CD137L is also expressed on most B-cell lymphomas (mantle cell, follicular, diffuse large B-cell) but absent in Hodgkin and T-cell lymphomas.
It is expressed in carcinoma cell lines and may be involved in T cell–tumor cell interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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