Thermo Fisher Scientific TH Monoclonal Antibody (OTI1A12), TrueMAB

Applications and Tested Dilution

Product Specifications

Target Information

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters such as dopamine, epinephrine, and norepinephrine. Catecholamine synthesis is regulated by the interaction of TH with tetrahydrobiopterin (BH4), which binds to the TH catalytic domain, resulting in enzymatic activity.
In humans, four TH mRNA splice variants (hTH1–hTH4) have been identified, differing in their N-terminal regulatory domains but sharing identical catalytic domains. TH catalyzes the conversion of L-tyrosine to L-dopa and plays a critical role in adrenergic neuron physiology.
Abnormalities in TH activity have been associated with neurological and cardiovascular diseases including Parkinson’s disease, schizophrenia, Segawa syndrome, dystonia, and others.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.