Thermo Fisher Scientific Petosemtamab Recombinant Human Monoclonal Antibody

Thermo Fisher Scientific Petosemtamab Recombinant Human Monoclonal Antibody

Applications

• ELISA (Assay-dependent)

Product Specifications

Product Specific Information

• Endotoxin level < 0.01 EU/µg by LAL method
• Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
• Store at 2–8°C for one week.
• Store at -20 to -80°C for twelve months from the date of receipt.

Target Information

Petosemtamab is a biosimilar that targets EGFR.
EGFR (Epidermal Growth Factor Receptor, HER1, ErbB1) is encoded by the EGFR gene located on chromosome 7 in humans.
EGFR belongs to the HER/ERbB family of proteins that includes ERbB2, ERbB3, and ERbB4. It is a transmembrane receptor; binding of ligands such as EGF and TGF-α to its extracellular domain induces dimerization and autophosphorylation of tyrosine residues in the cytoplasmic domain.
EGFR activation triggers multiple signaling cascades (Ras-ERK, PI3K-Akt, Jak-STAT, PKC) that regulate cell growth and proliferation.
Phosphorylation of EGFR at Y1086 allows GRB2 binding and MAPK pathway activation.
Activated EGFR undergoes endocytosis and is either degraded or recycled.
Mutations in EGFR are associated with lung cancer, and overexpression correlates with poor prognosis in various tumors, including those of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, and esophagus.

Usage Note

For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.