Thermo Fisher Scientific SET7 Polyclonal Antibody
SET7 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC 및 IHC(P) 실험에 적합. Human에 반응하며 Mouse, Rat 등 다양한 종과 교차 반응 가능. 항원 친화 크로마토그래피로 정제된 액상 형태로, 4°C 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 316 and 366 of Human SET domain containing (lysine methyltransferase) 7 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 50 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Bovine, Dog, Horse, Rabbit, Pig, Panda, Orangutan, Monkey, Gorilla, Chimpanzee, and Small-eared galago.
Target Information
Histone methyltransferase that specifically monomethylates Lys-4 of histone H3. H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activation of transcription. Has methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K motif in substrate proteins. Monomethylates Lys-189 of TAF10, increasing affinity for RNA polymerase II. Monomethylates Lys-372 of p53/TP53, stabilizing and enhancing p53/TP53-mediated transcriptional activation. [UniProt]
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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