Thermo Fisher Scientific SESN1 Polyclonal Antibody
SESN1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot에 적합하며 랫트 반응성을 보임. 합성 펩타이드 면역원으로 제작되어 높은 특이성과 재현성을 제공. 연구용으로 DNA 손상 및 산화 스트레스 관련 연구에 활용 가능.
- 카탈로그번호
- PA570072
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
- Western Blot (WB): 1.0 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human SESN1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2690460 |
Product Specific Information
This target displays homology in the following species:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Target Information
The SESN1 gene encodes a member of the sestrin family, which is induced by the p53 tumor suppressor protein and plays a role in the cellular response to DNA damage and oxidative stress. This protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase (AMPK), leading to inhibition of the mammalian target of rapamycin (mTOR). It also contributes to antioxidant defense by regenerating overoxidized peroxiredoxins. Expression of this gene may serve as a marker for radiation exposure. Alternatively spliced transcript variants encoding multiple isoforms have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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