Thermo Fisher Scientific KCNQ4 Polyclonal Antibody
KCNQ4 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 신경 흥분성 조절 연구에 적합합니다. Western blot에 최적화되어 있으며, 인간 및 설치류 등 다양한 종에 반응합니다. 합성 펩타이드 면역원 기반으로 높은 특이성과 재현성을 제공합니다.
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Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Hamster, Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human KCNQ4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2608447 |
Product Specific Information
Peptide sequence:
SSRMGIKDRI RMGSSQRRTG PSKQHLAPPT MPTSPSSEQV GEATSPTKVQ
Sequence homology:
Cow: 93%
Dog: 92%
Guinea Pig: 92%
Horse: 93%
Human: 100%
Mouse: 100%
Pig: 93%
Rabbit: 100%
Rat: 100%
Target Information
The protein encoded by this gene forms a potassium channel that plays a critical role in regulating neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel with the KCNQ3 gene product. Defects in this gene cause nonsyndromic sensorineural deafness type 2, an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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