Thermo Fisher Scientific CATSPER Polyclonal Antibody
CATSPER 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, ELISA에 사용 가능. 마우스 및 랫트 시료에 반응하며, 단백질 A로 정제된 액상 제품. 정자 기능 관련 칼슘 채널 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:400 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from mouse CATSPER (amino acids 451–550) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction, and chemotaxis toward the oocyte.
Activated by extracellular progesterone and prostaglandins in the order: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2.
Progesterone activation shifts voltage dependence toward more physiological, negative membrane potentials; this effect is not mediated by metabotropic receptors or second messengers.
Sperm capacitation enhances the progesterone effect by providing an additional negative shift. Also activated by elevated intracellular pH.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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