Thermo Fisher Scientific COL17A1 Recombinant Rabbit Monoclonal Antibody (ARC0233)
COL17A1 단백질을 표적하는 재조합 토끼 단일클론 항체로, Western blot, IHC, ELISA에 적합. HEK293 발현 시스템에서 생산되며 높은 특이성과 재현성을 제공. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0233 |
| Immunogen | Synthetic peptide corresponding to amino acids 1300–1400 of human Collagen XVII/COL17A1 (Q9UMD9) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.2 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849482 |
Product Specific Information
Immunogen sequence:
SVRRGSSYSS SMSTGGGGAG SLGAGGAFGE AAGDRGPYGT DIGPGGGYGA AAEGGMYAGN GGLLGADFAG DLDYNELAVR VSESMQRQGL LQGMAYTVQG P
Target Information
COL17A1 is the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein and a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane.
COL17A1 belongs to the FACIT collagen family (fibril-associated collagens with interrupted helices). It is localized to tissues containing type I collagen and may help maintain the integrity of the extracellular matrix.
Diseases associated with COL17A1 dysfunction include epithelial recurrent erosion dystrophy and epidermolysis bullosa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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