Thermo Fisher Scientific MCAM Monoclonal Antibody (OTI2B2), TrueMAB
인간 MCAM(CD146)을 인식하는 Mouse IgG1 단일클론 항체로 Western Blot 및 IHC(Paraffin)에서 검증됨. 액상 형태, 1 mg/mL 농도, PBS/BSA/glycerol 버퍼에 보관. 세포 접착 및 신호전달 연구용으로 적합.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific MCAM Monoclonal Antibody (OTI2B2), TrueMAB
Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2B2 |
| Immunogen | Full length human recombinant protein of human MCAM produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD146 (MCAM) is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. It is expressed at cell-cell junctions in endothelial cells and various normal and malignant cell types. CD146 functions as a calcium-independent adhesion molecule and may also participate in signal transduction through Fyn kinase activation and tyrosine phosphorylation of intracellular proteins involved in actin cytoskeleton assembly. It plays a key role in endothelial cell adhesion and vascular integrity, and its expression in melanoma cells may facilitate tumor metastasis. Additionally, CD146 may act as an adhesion molecule in neural crest cells during embryonic development and serve as a surface receptor triggering tyrosine phosphorylation of FYN and PTK2 with transient calcium influx.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.