Thermo Fisher Scientific CBX4 Polyclonal Antibody
CBX4 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF, ELISA 등 다양한 응용 가능. 고순도 Protein A 정제, 1 mg/mL 농도. 인간, 마우스, 랫트 반응성. 연구용으로만 사용.
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Thermo Fisher Scientific CBX4 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human CBX4 (amino acids 401–500) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Polycomb group (PcG) proteins are chromatin-associated proteins essential for stem cell self-renewal and maintenance. Two distinct human PcG complexes have been identified. Polycomb repressive complex I (PRC1) includes CBX4/Pc2, HPH1, and RING domain-containing proteins (RING1, RING2, BMI1).
CBX4 (Chromobox protein homolog 4 or PC2) functions as a transcriptional suppressor and E3 SUMO-protein ligase facilitating SUMO1 conjugation. Depletion of CBX4 reduces cellular resistance to ionizing radiation and affects DNA damage response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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