Thermo Fisher Scientific Tau Polyclonal Antibody

Thermo Fisher Scientific Tau Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, functioning as a linker between both. Axonal polarity is predetermined by TAU/MAPT localization in the neuronal cell body domain defined by the centrosome. Short isoforms allow cytoskeletal plasticity, while longer isoforms contribute to stabilization.

In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), which form neurofibrillary lesions in Alzheimer’s disease (AD) brains. Hyper-phosphorylation impairs microtubule binding, leading to destabilization and neuronal degeneration. Multiple kinases, including GSK-3β, PKA, cdk5, and casein kinase II, phosphorylate Tau. Hyper-phosphorylated Tau is found in neurofibrillary lesions of AD and other CNS disorders such as Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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