Thermo Fisher Scientific Tau Polyclonal Antibody
Tau 단백질을 인식하는 Rabbit Polyclonal Antibody로 인간, 생쥐, 랫트 반응성. WB, IHC, ICC, Flow 등 다양한 응용 가능. KLH 결합 합성 펩타이드(aa 1-100)로 면역화. 고순도 Protein A 정제, -20°C 보관.
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Thermo Fisher Scientific Tau Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Tau, amino acids 1–100 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, functioning as a linker between both. Axonal polarity is predetermined by TAU/MAPT localization in the neuronal cell body domain defined by the centrosome. Short isoforms allow cytoskeletal plasticity, while longer isoforms contribute to stabilization.
In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), which form neurofibrillary lesions in Alzheimer’s disease (AD) brains. Hyper-phosphorylation impairs microtubule binding, leading to destabilization and neuronal degeneration. Multiple kinases, including GSK-3β, PKA, cdk5, and casein kinase II, phosphorylate Tau. Hyper-phosphorylated Tau is found in neurofibrillary lesions of AD and other CNS disorders such as Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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