Thermo Fisher Scientific POLR3E Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:1,000

Product Specifications

Product Specific Information

• Recommended positive controls: Jurkat
• Predicted reactivity: Mouse (96%), Rat (96%), Zebrafish (82%), Xenopus laevis (80%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Specific peripheral component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters.
Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses.
Acts as nuclear and cytosolic DNA sensor involved in innate immune response.
Can sense non-self dsDNA that serves as template for transcription into dsRNA.
The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs), induce type I interferon and NF-κB through the RIG-I pathway.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.