Thermo Fisher Scientific AFF1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human AFF1 (AF-4) protein, validated for IHC (Paraffin). Unconjugated, liquid form with 1 mg/mL concentration. Suitable for leukemia-related research. For research use only.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from the N-terminal region of human AF4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555218 |
Target Information
Proto-oncogene AF-4 (also known as FEL) is a product of a chromosomal aberration of the human gene AFF1, associated with acute leukemias. The fusion of AF-4 on chromosome band 4q21 with the mixed lineage leukemia (MLL or HRX) gene on 11q23 results in a MLL-AF-4 chimeric transcription factor, where AF-4 contributes transcriptional effector properties and requires cell-specific accessory factors.
MLL is involved in several chromosomal translocations linked to acute myeloid and lymphoid leukemia. The MLL-AF-4 fusion protein is expressed in all normal hematopoietic cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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