Thermo Fisher Scientific SLAP Polyclonal Antibody
SLAP 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western Blot, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. Protein A로 정제된 액상 형태이며, 1 mg/mL 농도로 제공. 인간, 마우스, 랫트 반응성. TCR 신호 조절 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human SLAP (amino acids 21–120) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
SLAP (Src-like-adapter protein 1) is a 276-amino-acid adapter protein functioning as a negative regulator of T-cell receptor (TCR) signaling. Belonging to the SRC family of cytoplasmic tyrosine kinases, SLAP contains SH2 and SH3 domains. It colocalizes with endosomes and inhibits T-cell antigen receptor-induced activation of nuclear factor of activated T-cells. SLAP negatively regulates T-cell positive selection and mitosis, possibly by linking signaling proteins such as ZAP70 with CBL, leading to CBL-dependent degradation of signaling proteins. Expression is weak in heart, adult brain, placenta, liver, skeletal muscle, kidney, and pancreas, but high in lung and fetal brain.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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