Thermo Fisher Scientific HCAR2/HCAR3 Polyclonal Antibody
HCAR2/HCAR3 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot과 Immunocytochemistry에 적합합니다. 인간 시료에 반응하며, 액상 형태로 제공됩니다. PBS 기반 버퍼에 50% glycerol이 포함되어 장기 보관이 용이합니다.
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- PA599937
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human HCAR2 (Accession Q8TDS4), corresponding to amino acid residues F304–S354 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2818870 |
Product Specific Information
Antibody detects endogenous levels of total GPR109A/B.
Target Information
Acts as a high affinity receptor for both nicotinic acid (niacin) and (D)-beta-hydroxybutyrate. Mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. Also mediates nicotinic acid-induced apoptosis in mature neutrophils by reducing cAMP levels, affecting protein kinase A activity and phosphorylation of target proteins. The potency order for nicotinic acid binding displacement is:
5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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